Positioning

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OneEHR is a unified Python platform for longitudinal EHR experiments across ML, DL, and LLM agents.

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OneEHR is a unified Python platform for longitudinal EHR experiments. It provides shared infrastructure for preprocessing, modeling, analysis, and reproducible evaluation across AI agents, LLM systems, and conventional ML/DL models on one shared run contract — the first toolkit bridging classical machine learning, deep learning, and agentic AI for clinical prediction.

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Competitive Positioning

Dimension OneEHR PyHealth ehrapy
Focus Unified ML/DL/LLM evaluation DL model breadth Statistical EHR analysis
Models 25 (ML + DL + survival) 33+ (DL-focused) ~0 DL
LLM support Native (unified contract) None None
Datasets MIMIC-III/IV, eICU converters 10+ built-in loaders MIMIC via ehrdata
Medical codes ICD-9/10, CCS, ATC ICD, ATC, NDC, RxNorm, UMLS FHIR
Survival DeepSurv, DeepHit, KM None KM, Cox PH, AFT
Statistical tests DeLong, McNemar, bootstrap CI None GLM, ANOVA
Fairness 4 metrics + auto-detect None Bias detection + SMD
Interpretability SHAP, LIME, IG, attention 15+ methods Feature ranking
Causal inference Not in scope None DoWhy integration
Config TOML (complete contract) Python code Python code

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